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TPI.tv videos
Beginner
Pro tips for making a video about your research
Need some pro-tips to make your next video on animal-free innovations? Aniek and Victoria got some for you! In this video, they share why you should want to make a video about your research, tips about the content and format of an attractive video, and how to best share your video.
Innovation examples
HealthToxicology
Zebrafish in toxicity testing
Zebrafish are increasingly recognised as a useful model for toxicity testing of chemical substances. Testing strategies are becoming more based on mechanisms of toxicity structured in adverse outcome pathways describing the chain of events leading to toxicity or disease. Using a battery of dedicated in vitro and in silico assays, insight can be gained in how exposure leads to disease. For certain diseases it is known that toxicity relies on the interaction between different organs and cell types, which requires research on whole organisms in addition to simple in vitro models. The zebrafish is considered a valuable whole organism model in a mechanism-based testing strategy. At RIVM, the zebrafish embryo model is used for testing the effect of chemical substances on several adverse outcomes and diseases.
For more information see: https://ehp.niehs.nih.gov/doi/10.1289/EHP9888; https://doi.org/10.3390/ijerph18136717; www.linkedin.com/in/harm-heusinkveld
Innovation examples
HealthToxicologyIn vitro
Thyroid Hormone & Brain Development: animal-free models for human safety assessment
The environment can have a significant impact on a child's health even before birth. Brain development begins in the first trimester and continues until the age of 25, with thyroid hormone playing a critical role. During early pregnancy, the fetus depends on the mother's thyroid hormone, and a disruption in the thyroid hormone balance can lead to cognitive and motor impairments in the child. As part of the VHP4Safety project, we are developing in vitro tests to measure the developmental neurotoxic effects caused by disturbances thyroid hormone concentrations. Current testing guidelines do not always include testing for neurodevelopmental effects, highlighting the need for new non-animal methods. At the Erasmus Medical Center, human cell lines representing brain cell types are cultured to study the effect of chemicals on the thyroid hormone balance. RIVM uses human stem cells to create neuron-astrocyte networks that mimic brain development. By combining these different assays and models, we are creating a comprehensive human-based testing strategy to assess developmental neurotoxicity. These advances are a critical step toward eliminating animal testing while protecting the health and environment of future generations.
Innovation examples
HealthToxicologyIn silico
Predictive computer models for protein binding
In this video Linde Schoenmaker (Leiden University) explains how she and her colleagues are making computer models to predict the safety of new chemicals within the VHP4Safety project.
New
Innovation examples
HealthToxicologyIn silico
AI agents for safer science: How AI is Changing Chemical Risk Assessment
This video introduces a novel approach to chemical safety, where intelligent digital agents guided by large language models support scientists in making faster, more transparent decisions. By automating complex workflows and integrating tools like the OECD QSAR Toolbox, these agentic systems help prioritise research, reduce reliance on animal testing, and pave the way for safer, more sustainable innovation.
Innovation examples
ToxicologyPolicy
User Research in developing the virtual human platform
Digital tools can support the phasing out of animal-based tests and data in chemical risk assessment. This is one of the core promises of the Virtual Human Platform. The potential contribution of digitalization is linked to the acceptance and adoption of tools, methods, and data by stakeholders in several societal sectors. To facilitate the integration of stakeholders in the configuration of digital tools, Dr. Isaac Ortega Alvarado and colleagues gather insights from risk assessors in their role as users. Risk assessors are the ones who actualize chemical risk assessment and its standards through their practices. With this perspective, this research contributes to understanding the development and implementation of digital tools as embedded in social processes of construction and reception.
TPI.tv videos
Beginner
Pro tips for making a video about your research
Need some pro-tips to make your next video on animal-free innovations? Aniek and Victoria got some for you! In this video, they share why you should want to make a video about your research, tips about the content and format of an attractive video, and how to best share your video.
Projects and initiatives
HealthInnovationIn vitroOrgan-on-Chip
NXTGEN Hightech Biomed
The Netherlands has strong academic knowledge in areas like Lab-on-Chip, Organ-on-Chip, artificial organs, and cell production technology. However, turning this knowledge into actual products is challenging due to the need for collaboration between different technological and biological specialists. The NXTGEN Hightech program (https://nxtgenhightech.nl/en/biomed/) addresses this by creating a collaborative environment where companies from various fields work together. This approach aims to transform academic insights into innovative products, benefiting both the industry and society.