A New Way to Evaluate Chemical Safety and Assess Risk
Tony Kiuru (UPM Biomedicals)
Tony Kiuru discusses GrowDex, which is an animal free, ready to use hydrogel that mimics the extracellular matrix (ECM) and supports cell growth and differentiation with consistent results. Bridging the gap between in vitro and in vivo studies GrowDex can be used for 3D cell culture for spheroid and /organoids, in personalised medicine, regenerative medicine, organ-on-a-chip models, drug release studies, 3D printing and much more. GrowDex hydrogel is manufactured according to ISO13485. You can find more information about GrowDex at https://www.upmbiomedicals.com/siteassets/documents/growdex-brochure-2018.pdf and https://www.linkedin.com/company/growdex/ . General email address: email@example.com.
TPI.tv: improving science through animal-free innovations and research
Introducing TPI.tv : a video platform by experts striving to improve science through animal-free innovations and research.
Daniela Salvatori: TPI Utrecht
Prof. dr. Daniela Salvatori, chair of TPI Utrecht, presents the aims of the local TPI group and invites all who want to share their ideas or questions on the transition towards animal-free innovations to get in touch via uu.nl/tpi.
Wim de Leeuw: Aim and activities of TPI Utrecht
TPI Utrecht facilitates the Utrecht infrastructure to stimulate the transition to animal-free innovation. There is a helpdesk, a group of ambassadors, and a 3Rs Stimulus Fund. A digital marketplace for exchange of tissues is being developed, and as well a hybrid centre for biomedical translation, where there will increasingly be place for animal-free techniques.
Katja Wolthers (Amsterdam UMC) - virus research in human models: let's show some guts!
To study viruses that make people sick, we often use laboratory animals. However, virus infections in animals are different than in humans. New 3D culture models or 'organoids', which look like human organs in a petri dish, offer a unique opportunity to investigate how viruses enter the human body and cause disease. Our research focuses on enteroviruses such as polio. Due to vaccination, polio is rare, but other enteroviruses are increasingly a threat to young children and patients with impaired immune defenses. There are no medications available, because knowledge about infections with enteroviruses is limited. In our research we use organoids to see how enteroviruses enter the human body and by which means you can prevent that, without the use of laboratory animals. With this project we want to show that our technique can replace the use of laboratory animals in virus research.
Elly Hol (UMC Utrecht): possibilities for neuroscience
Prof. dr. Elly Hol (neuroscientist) talks about the opportunities for conducting animal-free research in Utrecht. She explains why it is necessary to use animal models next to cell-based models, for example for her Alzheimer research. More info at https://www.umcutrecht.nl/en/research/center/brain-center , http://translationalneuroscience.nl , http://www.ellyhollab.eu .
Whole blood assessment of thrombosis tendency
Transgenic animals are often subjected to short and long term experimental models of thrombosis and atherosclerosis with considerable discomfort to the animal. This project aims to: 1) replace (human blood instead of animal blood), 2) reduce (a few drops of blood per test), and 3) refine (replace in vivo by in vitro testing with isolated blood) the use of laboratory animals with two new small blood volume function tests—the perfusion chamber and the thrombin generation test. Both tests will be equipped with a simple detection capability, which is affordable for laboratories. Their application is not only in the field of thrombosis and haemostasis but also for the investigation of other blood-related diseases, such as arteriosclerosis, diabetes and cancer. By Sanne Brouns (Department of Biochemistry CARIM, Maastricht University, the Netherlands) and Linda Herfs (Flowchamber B.V.).
Charlotte Blattner (Harvard Law School)
Charlotte Blattner (Harvard Law School, Animal Law & Policy Program)
Erwin Roggen (ToxGenSolutions)
ToxGenSolutions provides a cutting-edge patchwork of test methods required for modern testing and assessment of compounds and products. It builds on a virtual generic platform of leading test and technology developers providing novel technologies addressing key events in outcome pathways. ToxGenSolutions products are proprietary mechanism-based gene signatures for identification and classification of toxicants during screening, product development and safety assessment. More information on https://toxgensolutions.eu/ .
Kirsten Baken (VITO)
Kirsten Baken (VITO, www.vito.be) discusses biomonitoring as part of the HBM4EU project (www.hbm4eu.eu). An example of the use of human biomarkers can be found at https://www.sciencedirect.com/science/article/pii/S0013935119302658 .
Five simple tricks for making your own video for TPI.tv
This video shows you how to make a video yourself. It's really not that difficult! See also https://tpi.tv/how-to-submit for additional information.