Innovation examples

Katja Wolthers (Amsterdam UMC) - virus research in human models: let's show some guts!
Innovation examples
HealthInnovation

Katja Wolthers (Amsterdam UMC) - virus research in human models: let's show some guts!

To study viruses that make people sick, we often use laboratory animals. However, virus infections in animals are different than in humans. New 3D culture models or 'organoids', which look like human organs in a petri dish, offer a unique opportunity to investigate how viruses enter the human body and cause disease. Our research focuses on enteroviruses such as polio. Due to vaccination, polio is rare, but other enteroviruses are increasingly a threat to young children and patients with impaired immune defenses. There are no medications available, because knowledge about infections with enteroviruses is limited. In our research we use organoids to see how enteroviruses enter the human body and by which means you can prevent that, without the use of laboratory animals. With this project we want to show that our technique can replace the use of laboratory animals in virus research.
02:314 months ago
Whole blood assessment of thrombosis tendency
Innovation examples
HealthInnovation

Whole blood assessment of thrombosis tendency

Transgenic animals are often subjected to short and long term experimental models of thrombosis and atherosclerosis with considerable discomfort to the animal. This project aims to: 1) replace (human blood instead of animal blood), 2) reduce (a few drops of blood per test), and 3) refine (replace in vivo by in vitro testing with isolated blood) the use of laboratory animals with two new small blood volume function tests—the perfusion chamber and the thrombin generation test. Both tests will be equipped with a simple detection capability, which is affordable for laboratories. Their application is not only in the field of thrombosis and haemostasis but also for the investigation of other blood-related diseases, such as arteriosclerosis, diabetes and cancer. By Sanne Brouns (Department of Biochemistry CARIM, Maastricht University, the Netherlands) and Linda Herfs (Flowchamber B.V.).
01:206 months ago
Samenwerking tussen Proefdiervrij en ZonMw
Innovation examples
Health

Samenwerking tussen Proefdiervrij en ZonMw

Meer Kennis met Minder Dieren. Een geweldig programma waardoor proefdieren worden vervangen. Waar gaat dit over? Wie doen hier aan mee? Bekijk onze video!
02:0715 months ago
Nederlandse Brandwonden Stichting en Proefdiervrij proosten op samenwerking
Innovation examples
HealthInnovation

Nederlandse Brandwonden Stichting en Proefdiervrij proosten op samenwerking

De Nederlandse Brandwonden Stichting is het eerste fonds dat hardop uitspreekt geen proefdieren meer te gebruiken. Zij hebben expliciet in het beleid opgenomen om te investeren in innovatief proefdiervrij onderzoek als kwalitatief betere onderzoeksmethode. Dit sluit naadloos aan op onze eigen missie. Door onze krachten te bundelen, kunnen we samen veel bereiken.
02:1415 months ago
VitalTissue wetenschappelijk onderzoek kan menselijk(er)
Innovation examples
Health

VitalTissue wetenschappelijk onderzoek kan menselijk(er)

VitalTissue wetenschappelijk onderzoek kan menselijk(er)
01:0015 months ago
Proefdiervrij onderzoek
Innovation examples
ToxicologyIn vitro

Proefdiervrij onderzoek

Voor betere bescherming van ongeboren baby. Onderzoek Victoria de Leeuw op het RIVM. Video gemaakt door Sophie Koster. Meer info: https://sophiekoster.nl/portfolio_page/proefdiervrij-victoria-de-leeuw-rivm/ . Artikelen uit dit werk op https://www.ncbi.nlm.nih.gov/pubmed/30578912 en https://www.ncbi.nlm.nih.gov/pubmed/31593710 .
02:2315 months ago